Fiocruz has established its headquarters in the campus located in Manguinhos in the North of Rio de Janeiro state, where are the historic buildings of the former Federal Serum Therapy Institute (Instituto Soroterápico Federal). - as the Moorish Pavilion, the Pavilion of the Clock and Stable. Other six units are in the cities of Rio de Janeiro, Belo Horizonte, Salvador, Recife, Manaus, Brasilia and Curitiba. Besides, there are new units that are being structured, as part of the national expansion project of Fiocruz, relating to policies for decentralization of research and training of human resources, promoted by the Federal Government. The new units of Fiocruz that are in development will be implemented in the states of Mato Grosso do Sul, Ceará, Rondônia and Piauí.
Fiocruz has as one of its missions to preserve heritage buildings regarded to its history and its fields of activity. The campuses of the Foundation in Rio de Janeiro, in addition to harbor important architectural specimens of various periods, have high potential urban and landscape. The preservation of this heritage is responsibility of technical staff of the Department of Historical Heritage (DPH) of the Oswaldo Cruz House.