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IBMP/Fiocruz delivers inputs for the diagnosis of Monkeypox


IBMP and Fiocruz


As the first suspected cases of the monkeypox virus appear in Brazil, Fiocruz, through the Molecular Biology Institute of Paraná (IBMP, in the Portuguese acronym), has joined efforts in another pioneering initiative and has produced, in just a week, positive controls to help safely diagnose the disease. The first reagents were delivered to the Pan-American Health Organization (PAHO), the regional office of the World Health Organization (WHO), to be distributed to at least 20 countries. Another batch of positive controls was distributed today, June 8, to reference laboratories in Brazil, at the request of the General Coordination of Public Health Laboratories (Secretary’s Office of Surveillance in Health/Ministry of Health).

Technicians from national health institutes of seven countries were trained at Fiocruz, in association with PAHO and the Brazilian Ministry of Health, for the laboratory diagnosis of the virus.

The first reagents were delivered to Paho to be distributed to at least 20 countries (Image: IBMP)

Elaborated in record time, these positive controls reflect the national capacity to produce critical pharmaceutical inputs for diagnostics. “This strategic action, which was started after all we learned regarding the supply chain experienced in the COVID-19 emergency, has now materialized in the strengthening of the local productive arrangement and has expanded the country’s capacity to respond to public health emergencies. This is an important step for autonomy and for independence in the local production of diagnostic tests”, emphasized Fiocruz president, Nísia Trindade Lima.

Positive controls are an important element that ensures the reliability of the reaction in molecular tests (qPCR), preventing possible errors from occurring and from interfering with the result. The material developed by the IBMP is only destined for use in research, under the responsibility of reference laboratories in Brazil and in Latin America, for the control of the monkeypox virus.

Positive controls ensure the reliability of the reaction in molecular tests (qPCR)

“We used our expertise and raw materials to develop diagnostic kits, together with what is published in international scientific literature, to produce quality reactions that make the molecular diagnosis of monkeypox precise and safe”, explains the manager of Technological Development of IBMP, Fabricio K. Marchini.

There are currently four laboratories in Brazil that can diagnose the disease: Viral Molecular Biology Laboratory of the Carlos Chagas Filho Biophysics Institute, at the Federal University of Rio de Janeiro (LBMV/IBCFF/UFRJ), the Central Public Health Laboratory of Minas Gerais/Ezequiel Dias Foundation (Lacen/Funed-MG), the Central Public Health Laboratory of São Paulo/Adolfo Lutz Institute (Lacen/IAL-SP), and the Enterovirus Reference Laboratory of the Oswaldo Cruz Institute (IOC/Fiocruz).

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